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• in virtually any solvent
• in flow systems
• in repeated use

Successful use of Sabit DVB-TBD to catalyze the formation of trichloroacetimidates from alcohol and trichloroacetonitrile. Work conducted by Prof. Christian Pedersen at University of Copenhagen, Denmark.

Results: using this new rigid resin with bound TBD led to efficient catalysis of the reaction with high % of conversion to product, without cumbersome product and catalyst separation. Read the full story with all details in our recent open access publication in Chemistry Methods 2026.

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Redstone Separations presents the extension of the portfolio on peptide synthesis resins and described a new hydrophilic SPPS resin prototype based on acrylamide backbone and offers early adopters to obtain a sample for validation and feedback.

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TBD is a bicyclic guanidine base and is one of the so-called superbases with a pKa value of 25. We provide TBD covalently immobilized on an optimized porous polymeric resin for facilitated catalysis, where the resin-bound catalyst can be easily removed from the reaction mixture avoiding cumbersome chromatographic or other purification steps.

SABIT DVB-TBD can be used to catalyze a number of reactions, such as Wittig reactions, Michael additions, Henry reactions and transesterifications. Resin-bound TBD is easily separated from substrates and product, facilitating the handling and work-up of product. The resin can be used instead of free TBD or TBD bound to soft resins with only 1-2 % DVB – but these low cross-linked resins are not compatible with all solvents and do sometimes not perform well for certain reactions. 

On the other hand, the morphological rigidity and permanent porosity of SABIT DVB-TBD enables its use in a much wider range of solvents. For certain reaction processes and solvent it may be the only tool available to catalyze a desired reaction.

Further, this novel resin-bound base can also be employed as a strong anion exchanger and thus as a scavenger for for negatively charged compounds for catch and release processes. Its unique structure and high surface loading of TBD groups renders it water-wettable and this allows for effective binding in both polar or aqueous solutions and non-aqueous solvents.

Expert evaluation of SABIT DVB-TBD

The group of Prof. Christian Marcus Pedersen at Copenhagen university conducted the first evaluation of catalysis using this novel resin-supported superbase with outcomes of practical utility to the organic chemistry community. Sabit DVB-TBD is thus an additional tool for organic chemists. With it rigid resin structure at ca 50 % cross-linking it is usable in many more solvents than soft resin-bound superbase products with less than 1 % or 2 % DVB cross-linkage (from Merck or Biotage). The high cross-linkage ensures bead stability and open pores under almost any common solvent environment. 

Activation and regeneration of SABIT DVB-TBD for re-use

Before and after use, polymer-supported TBD resin may be (re-)activated with a strong base. Use each time ca 5 ml/g resin of the given solution to the resin. Let interact for a short while (few minutes) while shaking or stirring, then filter off or decant resin for next step. 

Typical application conditions

• Use 2-10 equivalents of catalyst to limiting reactant
• React for 1 – 20 hours while stirring or shaking
• Reaction at room temperature or to max 90 C 
• All common solvents are possible to use
• Resin is easily water-wettable and thus also directly compatible with aqueous mixtures
• After reaction, filter off resin, or let resin sediment, then decant
• Re-activate resin for re-use following above suggested regeneration procedure

Representative procedure: catalysis of a reaction

The first model reaction shown is the reaction of an alcohol with trichloroacetonitrile to a trichloroacetimidate. These results were developed by Prof. Christian Pedersen, Copenhagen University, Dept. Chemistry. 

Acetimidates are commonly synthesized and used as intermediates for heterocycle synthesis or as reagents for alkylation reactions 

Approximately 5 equivalents of DBV-TBD base are used with respect to alcohol and reacted for 1 hour at room temperature in a green, non-toxic (food-grade) solvent, propyl-acetate. Yield is ca 75 %. Higher yields may be obtained with longer reaction times and higher temperatures.

Sabit DVB-TBD efficiently catalyzed the reaction in different solvents and also green solvents like n-propyl acetate worked better than the reaction catalyzed by conventional PS-DBU. 

The results are published in 2026 in Chemistry Methods and is open access. Pls contact Prof. Pedersen at Copenhagen University for more details on his work. 

Purchase and price list:

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Pls inquire for more information or if you require resin packed in column. For more advantageous pricing of larger quantities and to discuss a quote, please contact us at: info@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)

Redstone Separations is expanding its portfolio on peptide synthesis resins and presented new hydrophilic SPPS resin concepts and offers collaborations to co-develop tailor-made resins based on acrylamide combinations.

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SABIT PS-DVB AM: A New Choice in Solid Phase Peptide Synthesis

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Redstone Separations AB is thrilled to launch SABIT DVB-TBD, a novel, rigid polymer-supported Triazabicyclodecene superbase engineered to streamline chemical synthesis. It features permanent porosity and stability across all common solvents, ensuring consistent, superior performance. It obviates cumbersome purification stesps and is re-usable to increase sustainability and economics.

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New Application Note: Efficient Organic Compound Recovery from Water

Redstone introduces a novel method for extracting organic compounds from water using its hydrophobic resin DVB-Sty MP-002. Demonstrated with gallic acid, the resin enables over 97% recovery via acetone—without evaporating bulk water. This reusable, scalable solution supports water-based synthesis, enzyme reactions, and purification workflows across lab and industrial settings.

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We’ve officially moved into our brand-new labs! With cutting-edge facilities and expanded capabilities, we’re now equipped to accelerate product development and deliver even better service to our partners and customers. This move marks a major step forward in our commitment to innovation and quality. And with several exciting new products already in the pipeline, the future looks brighter than ever.

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