SABIT™ DVB-TBD

Material overview

SABIT DVB-TBD is a rigid polymeric resin with surface bound superbase TBD (Triazabicyclo[4.4. 0]dec-5-ene) for use in catalytic reactions or as a novel strong anion exchanger. The resin chemistry backbone consists of highly rigid DVB-Styrene with mesopores and a well accessible surface in essentially all solvents. It constitutes a new polymer-bound catalyst with more robust physical properties than other polymer-supported bases. 

Table of properties

Property

SABIT DVB-TBD

Resin backbone

DVB/Sty

Particle size

75-200 µm

Volume of resin, dry

2.1 ml/g

Volume of resin, swollen in EtoAc

2.9 ml/g

Pore volume

1 ml/g

Pore area

600 m2/g

Av pore size

80 Å

Surface chemistry of SABIT DVB-TBD, with covalently immobilized TBD. Loading ca 1 mmol/g. 

Application areas

SABIT DVB-TBD can be used to catalyze a number of reactions, such as Wittig reactions, Michael additions, Henry reactions and transesterifications. Resin-bound TBD is easily separated from substrates and product, facilitating the handling and work-up of product. The resin can be used instead of free TBD or TBD bound to soft resins with only 1-2 % DVB – but these are not compatible with all solvents and do sometimes not perform well. The morphological rigidity and permanent porosity of SABIT DVB-TBD enable its use in a much wider range of solvents and for certain reaction processes it may be the only tool able to catalyze a desired reaction.

Further, this novel resin-bound base can also be employed as a strong anion exchanger and thus as a scavenger for catch and release processes. As described, its unique structure and good water-wettability allow for effective binding in both polar aqueous and non-aqueous solutions.

Activation and regeneration of SABIT DVB-TBD for re-use

Before and after use, polymer-supported TBD resin may be (re-)activated with a strong base (each time ca 5 ml/g resin):

Step

Organic base regeneration

Water-based regeneration

Strong base wash

5% MeONa in MeOH

1 M NaOH, aqu.

Removal of base

3 x MeOH

5 x water

Removal of organics

Optionally DCM

3 x MeOH

Drying

RT or 70 °C oven

RT or 70 °C oven

Typical application conditions

  • Use 2-10 equivalents of catalyst to limiting reactant
  • React for 1 – 20 hours while stirring or shaking
  • Reaction at room temperature or to max 80 C (possibly higher – to be determined)
  • All common solvents are in principle possible to use
  • Resin is easily water-wettable and thus also compatible with aqueous mixtures
  • After reaction, filter off resin, or let resin sediment, then decant
  • Re-activate resin for re-use following suggested regeneration procedure

Go to shop

Or order directly by email: order@redstone-sep.com

Pls inquire for more information or if you require resin packed in column. For more advantageous pricing of larger quantities and to discuss a quote, please contact us at: info@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)