Temiz Tosylate

Material overview

TEMIZ Tosylate is a rigid polymeric resin with strong acid (pka < 1) functionalities for use in various organic synthesis and scavenging reactions. 

The resin chemistry backbone consists of highly stable DVB-Sty with an exceptionally high amount of tosylic acid groups (higher than all other competitor materials).

Application areas

Temiz Tosylate is the resin bound version of p-toluene sulfonic (tosylic) acid and can be conveniently used instead of the soluble acid. As an acid catalyst it can be used for the synthesis of small molecules, with examples such as etherification or alkylation. 

Temiz Tosylate can also be used for quenching or scavenging of cationic organic molecules or other compounds as an alternative to soluble acids. It can be used in “catch and release” applications. The strong sulfonic acid groups are well accessible for removal of basic compounds such as amines including anilines, borohydrides, but also metals.

The high loading of well accessible tosylic acid groups in a stable resin matrix makes it an economically viable material with superior cost-in-use for different types of applications. The large particles are optimal for easy handling, fast sedimentation and preparative applications.

Representative catch experiment in suspension mode:

1. Weigh 1 g resin (4 mmol capacity)
2. Wash with 3 x 3 ml methanol, decant
3. Add 4 ml methanol containing 1.5 mmol amine compound
4. Binding time 1 h under gentle shaking
5. Let resin settle or decant, analyze supernatant

Result of catch experiment. All amine compounds (dopamine, nicotine, picolylamine and cotinine) were bound 100 %. 

Elution with dilute ammonia releases amines quantitatively.