Solid Phase Support Materials
Solid phase synthesis material concepts
Redstone Separations AB develops and produces solid phase synthesis resins for various types of supported, step-wise chemical reactions and synthesis. The most prominent application area is the preparation of API peptides and oligonucleotides.
| Current product example | New concepts and prototype materials |
|---|---|
| PS with 1 % DVB With high swelling, but poor for flow | 5 – 10 % DVB or more With lower swelling, but good for flow |
| TentaGel PEGA ChemMatrix (discontinued) | PDMA bead variants for hydrophilic SPPS With higher loadings, adjustable swelling New alternative to discontinued resins (ChemMatrix) |
| NittoPhase | DVB/PS AM medium rigidity For oligonucleotide solid phase synthesis For solid phase peptide synthesis in flow |
By maintaining in-house control over every stage of production, we ensure a level of predictability and quality that the market demands. Custom variants are also available with industry-leading lead times to deliver solutions in a short time.
If you want to be a part of early adopters of new materials and give feedback, contact us to obtain prototype materials for testing: info@redstone-sep.com
Scanning electron microscope image of the porous surface of a rigid, large pore resin. Particle size 100 um, magnification 50 000x, pore size approximately 500 to 1000 A.
Novel hydrophilic concepts
An example of novel hydrophilic concepts and ideas of beaded materials was presented in a poster at the Danish Peptide Symposium, April 2026 in Copenhagen, Denmark.
Hydrophilic / hydrophobic spectrum concept overview
- Fully hydrophilic with PDMA and amide based amine anchor
- Mainly hydrophilic with PDMA backbone and aromatic hydrophobic benzyl amine anchor
- Mainly hydrophobic PS backbone with hydrophilic amide based amine anchor
- Mainly hydrophobic PS backbone with aromatic benzyl amine anchor
Variations and combinations on rigidity/swelling, hydrophilicity tuning, loading and alternative surface chemistries are possible to design and to provide for testing.
A speculation is that the adaptation to the right hydrophilicity / hydrophobicity balance might be beneficial for the synthesis of certain difficult peptides.
Contact us to get your copy of the poster, or with other inquiries: info@redstone-sep.com
Poster presented at the Danish Peptide Symposium 2026.
SABIT PDMA: hydrophilic SPPS resin
SABIT PDMA is a new highly polar solid phase synthesis resin for peptides or other compounds, and a potential alternative to discontinued ChemMatrix or PEGA resins.
- Swelling in polar/aqueous solvents can be engineered to 5 ml/g, 8 ml/g or other values on request
- Spherical shape with improved mechanical stability compared to alternative equivalent materials
- Standard particle size distribution 75-300 µm, other sizes on request
- Highly hydrophilic, consisting only of cross-linked dimethylacrylamide functionalized with aliphatic aminoethyl groups
- Loading currently 0.5 mmol/g of primary aminoethyl groups, higher or lower loadings can be provided
Other uses: on-bead assays, direct enzymatic screenings, combinatorial library assays, and as affinity solid phase in chromatography.
Spherical cross-linked poly-dimethylacrylamide SPPS resin beads.
Tailor-made resins
Redstone uses proprietary resin architecture technology to provide alternative, novel or improved performance. Resins can be adapted to a specific peptide sequence to improve production economics, since each peptide may need its own optimal resin. Adaptations can be made to cross-linking, loading, backbone chemistry, resin architecture, particle size or linker type.
A broad variety of solid phase support materials can be designed and supplied, including at industrial scale, with a fast turnaround. We offer custom synthesis of a solid support material adapted for your application. See our tailored resin service.
Stay tuned for more products, or inquire for custom-made variants.
Products in this family
From 95,00 € excl. VAT
From 95,00 € excl. VAT
Price range: 75,00 € through 2 500,00 € excl. VAT
From 125,00 € excl. VAT
From 90,00 € excl. VAT
From 90,00 € excl. VAT
250,00 € excl. VAT
TAILORED RESINS