TEMIZ™ Karbonik

TEMIZ Karbonik is a mesoporous, rigid polymeric resin for use in scavenging reactions.

The capacity if far higher than competitors materials.

Resin matrix

DVB/Sty

Resin surface chemistry

Q ammonium carbonate

Particle size

200-1250 µm

Porosity

Mesoporous

Capacity, dry

ca 4 mmol/g

The resin chemistry backbone consists of highly stable DVB-Sty with an exceptionally high amount of positively charged polymeric quaternary amines coordinated to negatively charged carbonate counterions. 

Application areas

This polymer-bound base with its new structure offers higher capacities and faster exchange reactions. The easily accessible carbonate ions are bound to quaternary tetramethyl ammonium groups easily accessible on the resin surface. 

Temiz Karbonik is a resin-bound alternative to tetra-alkylammonium carbonate and can be used to scavenge a variety of acidic molecules such as

  • acidic phenols, HOBt
  • carboxylic, boronic, trifluoroacetic, hydrochloric acids

Further, it can be used as a general base to quench reactions and to neutralize amine hydrochlorides ie free basing.

The large particles of TEMIZ Karbonik are optimal for facilitated handling and in preparative applications.

Representative Procedure:

Neutralization of Amine Hydrochloride Salt to free amine

  1. Basic drug hydrochloride salt (1 equiv.) in DCM or MeOH
  2. Add Temiz-Karbonik (2-5 equiv.), shake gently for 1-2 hours
  3. Separate resin by filtration or sedimentation
  4. Wash 2x with DCM or MeOH.
  5. Concentrate the filtrate to give the free base.

Price list Karbonik Scavenger: 

  • 5 g = 350 €
  • 25 g = 1 000 €
  • 100 g = 4 000 €
  • 1 kg = 25 000 €

More advantageous prices given for larger quantities – to discuss a quote, please contact us.   

Pls inquire for more information or if you require resins packed in column.

Order at: order@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)