solid phase support materials

Redstone Separations AB develops solid phase synthesis resins for various types of supported step-wise chemical reactions and synthesis. The most prominent application area is the prepration of API peptides and oligonucleotides up to a certain length. 

Conventional solid phase peptide support resins are polymeric materials with low levels of cross-linkage, which are the standard today for conventional solid phase peptide synthesis. As gel-type materials, these do not display distinct pore sizes but have certain swelling characteristics in various solvents.

Novel solid phase supports are highly cross-linked, have large pore resins and are aimed at implementation in oligonucleotide synthesis but could also be envisaged for use in novel flow peptide synthesis or for other molecules that benefit from a rigid bead structure.

Current development portfolio has the following highly cross-linked polymeric resins in the pipeline:

  • DVB/Styrene reversed phase resins
  • X-link variations:
    • low cross-linkage (1 or 2 %)
    • high cross-linkage (eg 50 %)
  • Particle sizes:  20-45 µm / 45-70 µm / 70-200 µm or larger
  • Porosity:
    • gel-type
    • mesoporous 20-500 Å
    • macroporous 500 Å to 1000 Å
    • also >1000 Å (upon inquiry)
  • Capacity: 0.1 mmol to 2 mmol/g 
  • Other properties: upon request

Standard surface functionality: NH2.

Other surface functionalities can be discussed.

Example: Scanning electron microscope picture of the porous surface of a rigid, large pore resin 

  • Particle size: 100 µm 
  • Magnification 50.000 x
  • Pore size: approximately 500 – 1000 Å

Redstone Separations employs proprietary synthetic resin architecture technologies in the resin production for novel or improved performance. 

A broad variety of solid phase support materials can be designed and provided, also at large industrial scale. 

Stay tuned for first products or inquire for custom-made variants.

We offer custom synthesis of a solid support material adapted for your application. Pls see our offering of custom made tailored resin service.

Pls inquire for further questions: 

Email: info@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)