SABIT-SPPS Resins are novel resins optimized for solid phase peptide synthesis. All resins are made from scratch in our labs and production facilities in Lund, Sweden. This ensures full control and reproducibility of each synthetic step or scale of manufacturing of the products. It also enables us to provide custom-made variations and tailored solutions to specific peptide sequences.

SABIT PDMA resins are fully hydrophilic resin beads and are co-polymers of dimethylacrylamide made with proprietary bead formation and novel resin architecture technology. Current variant has aminoeethyl functional groups for coupling of a linker prior to peptide synthesis. An polymeric dimethylacrylamide backbone mimics the peptide backbone with its abundant amide bonds, it interacts excellently with highly polar solvents such as DMF, DMA and NMP. It is expected to effectively prevent peptide aggregation by creating a strongly solvated, peptide-like environment.

Current amino loading is at 0,5 mmol/g and is well controllable and predictible, which gives the user the potential for better predictablity in production economy in preparative solid phase peptide synthesis. An accurate loading level allows the user to properly dose expensive amino acid building blocks, coupling agents and solvents at the most economic level. This contributes to improved economics, environmental sustainability and work safety in the peptide industry. 

This product class is believed to be a possible alternative to discontinued ChemMatrix or PEGA resins. Also, it may be considered a potential alternative to other hydrophilic resins such as Tentagels or other composite resins that consist of cross-linked polystyrene backbone with grafted PEG constructs. 

An often observed adverse peptide synthesis such as aggregations or other phenomena may be diminished with fully hydrophilic resin environments of the growing peptide chain. Hence, an aim is to improve the yield and purity of long, complex, and hydrophobic (“difficult”) peptides. With a resin environment that essentially matches dimethylacetamide or dimethylformamide it may overcome the physical and chemical limitations inherent to traditional polystyrene (PS)-based resins. As a peptide chain grows, it tends to fold into secondary structures (eg beta-sheets) and aggregate. The hydrophilic networks of PDMA-based matrices are expected to repel the growing peptide backbone, keeping it extended and accessible for successive amino acid couplings.