SABIT™ Karbonik

SABIT Karbonik is a mesoporous, rigid polymeric resin for use in scavenging reactions, especially for neutralizing amine hydrochlorides and scavenging acids. 

The properties of the material are listed in the table below.

Resin matrix

DVB/Sty

Resin surface chemistry

Q ammonium carbonate

Particle size

400-1200 µm

Porosity

Mesoporous

Capacity per g, approx

2.2 mmol/g

Capacity per ml, approx

0.8 mmol/ml

Resin density, approx

0.38 g/ml

Dry volume

2.6 ml/g

Swelling in water

4.6 ml/g

Swelling in MeOH

4.2 ml/g

Redstone can deliver materials that are for example higher in capacity or more rigid or have a smaller particles size. Please contact us for such tailor made materials.

The resin chemistry backbone consists of highly stable DVB-Sty with an exceptionally high amount of positively charged polymeric quaternary amines coordinated to negatively charged carbonate counterions. 

Application areas

This polymer-bound base with its new structure offers higher capacities and faster exchange reactions. The easily accessible carbonate ions are bound to quaternary tetramethyl ammonium groups well accessible on the resin surface. 

Sabit Karbonik is a resin-bound tetra-alkylammonium carbonate and can be used to scavenge a variety of acidic molecules such as

  • acidic phenols, HOBt, etc
  • carboxylic, boronic, trifluoroacetic, hydrochloric acids

Further, it can be used as a general base to quench reactions and to neutralize amine hydrochlorides ie free basing.

The large particles of Sabit Karbonik are optimal for facilitated handling and in preparative applications.

It is a viable alternative to other resin bound reagents such as MP Carbonate variants or Tetraalkylammonium carbonate, polymer-bound products on the market. Some suppliers discontinued their supply and our product represents an alternative or replaces that gap for the users. 

Representative Procedure:

Neutralization of Amine Hydrochloride Salt to free amine

  1. Basic drug hydrochloride salt (1 equiv.) in DCM or MeOH
  2. Add Sabit-Karbonik (2-5 equiv.), shake gently for 1-2 hours
  3. Separate resin by filtration or sedimentation
  4. Wash 2x with DCM or MeOH.
  5. Concentrate the filtrate to give the free base.

Link to product pdf.

Purchase and price list:

Go to shop

Or order directly by email: order@redstone-sep.com

Pls inquire for more information or if you require resin packed in column. For more advantageous pricing of larger quantities and to discuss a quote, please contact us at: info@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)