Solid Phase Synthesis Materials

Redstone Separations AB develops solid phase synthesis resins for various types of supported step-wise chemical reactions and synthesis. The most prominent application area is the prepration of API peptides and oligonucleotides up to a certain length. 

Conventional solid phase peptide support resins are polymeric materials with low levels of cross-linkage, which are the standard today for conventional solid phase peptide synthesis. As gel-type materials, these do not display distinct pore sizes but have certain swelling characteristics in various solvents.

Novel solid phase supports are highly cross-linked, with large pores aimed at implementation in oligonucleotide synthesis could also be envisaged for use in novel flow peptide synthesis or for other molecules that benefit from a rigid bead structure or from being used in a flow system.

By maintaining total in-house control over every stage of production, we ensure a level of predictability and quality that the market demands. Custom variants are also available with industry-leading lead times.

Our current development portfolio has the following cross-linked polymeric resins in the pipeline:

  • DVB/Styrene reversed phase resins
  • X-link variations:
    • low cross-linkage (1 or 2 %)
    • high cross-linkage (eg 50 %)
  • Particle sizes:  20-45 µm / 45-70 µm / 70-200 µm or larger
  • Porosity:
    • gel-type
    • mesoporous 20-500 Å
    • macroporous 500 Å to 1000 Å
    • also >1000 Å (upon inquiry)
  • Capacity: 0.1 mmol to 2 mmol/g 
  • Other properties: upon request

Standard surface functionality: NH2.

Other surface functionalities or linkers can be discussed.

Example: Scanning electron microscope picture of the porous surface of a rigid, large pore resin 

  • Particle size: 100 µm 
  • Magnification 50.000 x
  • Pore size: approximately 500 – 1000 Å

 Tailor-made resins

Redstone Separations AB employs proprietary synthetic resin architecture technologies in the resin production to provide alternate, novel or improved performance. Redstone Separations AB offers tailor-made resins that can be adapted to eg specific peptide sequences to optimize production economics – as each peptide may require an optimal resin for production. Adaptations can be on: cross-linkage, loading, back-bone chemistry, resin architecture, particle size or type of Linker.  

A broad variety of solid phase support materials can be designed and provided, also at large industrial scale. We offer custom synthesis of a solid support material adapted for your application. We can provide novel resins with a fast turn-around time. 

Pls see our offering of custom made tailored resin service.

 

Stay tuned for more products or inquire for custom-made variants. 

Email: info@redstone-sep.com 

Phone: +46-738-156-130  (Call times during CET: 8.00 – 18.00)